In this article, Upperton interviewed Dr Ian Lafferty, our Chief Technical Officer on the topic of developing spray dried dispersions (SDDs) into tablets. Ian has 25 years of technical and operational experience in early-phase pharmaceutical development encompassing the formulation design, development, process optimisation and manufacture of a wide range of dosage forms including oral solids … Read more
News 25th February 2020 – Applications and Techniques of Pharmaceutical Granulation Granulation has been widely used in the pharmaceutical industry since the 1950s. Whilst the science remains largely identical to that developed over 70 years ago, granulation techniques and equipment have improved to allow for a greater number of applications in both R&D and manufacture. … Read more
News 11th February 2020 – Tablets: A General Formulation Overview Tablets continue to be one of the most popular pharmaceutical dosage forms, as with the right tablet formulation you can achieve: ease of handling and administration for patients, stability convenient packing options, and well-established cost-effective manufacturing processes which produce consistent quality products. However, there are … Read more
News 28th January 2020 – Tablets: A General Overview Tablets are one of the most popular dosage forms used in the pharmaceutical industry due to their: ease of handling and administration for patients, stability, convenient packing options and well-established cost-effective manufacturing processes which produce consistent quality products. However, there are also disadvantages to presenting a … Read more
Oral Solid Dosage Forms Containing Amorphous Spray Dried Dispersions: Choices for First in Human Studies The number of amorphous solid dispersions entering first in human (FIH) studies continues to increase, due to the growing number of novel APIs with a poor solubility profile, and associated bioavailability challenges. Spray drying is a useful technology for creating … Read more
News 12th December 2019 – Assessing Enabling Technologies using the UpperSolv™+ Screening Platform for Increasing Bioavailability Currently approximately 9 out of 10 new drugs entering clinical trials will fail before reaching approval. Many of these drugs will fail due to problems with ADME (absorption, distribution, metabolism and excretion) rather than lack of efficacy. One of … Read more
10th December 2019 – Press Release Upperton Pharma Solutions, a UK-based contract development and manufacturing organisation (CDMO) are launching an enabling technology screening protocol which aims to support companies with the rapid development of both standard and complex drug products. The new enabling technology screening protocol, integrates the company’s existing formulation capabilities with a biopharmaceutical … Read more
Pulmonary delivery is showing increased popularity as a viable dosage form for treating local airway diseases and offers additional potential for systemic drug delivery. Within this space there are a number of delivery approaches that can be undertaken. These include dry powder inhaled formulations (DPI) and pressurised metered Dose Inhalers (pMDIs). Each of these delivery … Read more
News 28th November 2019 – Selecting a Spray Dryer for Development Studies and Clinical Manufacture When customers initiate discussions with Upperton, one of the first questions we are asked is “which spray dryer(s) do you have and how much material can they produce?” Whilst these are very pertinent questions, the answer is not a simple … Read more
News 19th November 2019 – API Challenges during early formulation development, Part 2 There are many challenges that face companies taking a NCE into early stage feasibility testing and beyond. Some of these challenges are specific to the physical and chemical properties of the molecule in question (e.g. hard to handle API) whilst other challenges … Read more
Albert Einstein Centre, Nottingham Science Park, Nottingham, UK NG7 2TN,
Phone: +44 (0) 115 855 7050
Email: contact@upperton.com
Copyright © 2024 Upperton Limited. All rights reserved.
