Clinical Manufacturing & Packaging

Clinical Supplies Manufactured with Compliance and Quality

Upperton offers a flexible and dynamic approach to GMP manufacturing. From first in human (FIH) through to phase III clinical supplies manufacturing. No project is too small or too challenging.

Upperton has been granted licences from both the Medicines and Healthcare products Regulatory Agency (MHRA) and the Home Office (controlled drugs I-IV)

Upperton MHRA Licence: Scope of Activities

In our MHRA approved facility, we offer manufacturing and packaging of Investigational Medicinal Product (IMP) in dosage forms including oral solid dosage forms, bulk dry powders, dry powder inhalers, nasal suspensions and solutions; for both biological molecules and traditional small molecules. Placebo development and manufacture are also offered.

GMP Clean Room Facilities

We currently have 3 x Grade D/ISO 8 manufacturing rooms with 2 x Grade C/ISO 7 downflow booths for manufacturing of a wide range of dosage forms including

  • Bulk spray dried powders
  • Capsules
  • Tablets
  • Dry Powder Delivery Devices (nasal and pulmonary)
  • Liquid Delivery Devices (nasal and pulmonary)

Where necessary, localised isolator technology can be utilised for operator protection (eg when handling more potent molecules) or for reducing bioburden when manufacturing liquid formulations.

Processing Technologies

Our manufacturing suite is incredibly flexible with a wide range of mobile equipment that can be brought in and out of our facility depending on our customers processing requirements. Here are some of the processing technologies that we have available

  • Granulation
    – GP1 High shear Mixer granulator (10 L)
    – TFC micro roller compactor

  • Blending
    – Pharmatech MB30 – up to 30 Kg

  • Compression
    – Futorque Rotary machine 130,000/H

  • Coating
    – O’Hara LC M5 multi pan coater (5 kg)

  • Capsule / Device filling
    – Quantos, 3P F2W Bonapace INCAP (3000/hr)

  • Spray Drying
    – ProCepT spray dryer (100 mg to 200 g)
    – SD Micro Spray dryer (10 g to 500 g)
    – GEA Niro PSD1 (50 g to 3 kg)
For more details on the range of manufacturing capabilities and processes that we can offer, please download our Technical Services Fact Sheet

Pre-Formulation Studies

Upperton’s formulation development team will confidently guide you on the best route forward.

Formulation Development

Utilise our expertise and know-how to solve problems unique to your challenging molecule.

Oral Dosage Forms

Development of oral dosage forms containing spray dried powders. Including tablets, capsules, sachets and vials.

We’re here to help

If you’re looking to work with a CDMO that can support your product from preclinical development to the clinic and beyond, then we’re here to help.
Speak to our team to discuss your requirements.

Let's Talk.

Book a discovery call.

To speak with a member of our team and talk about a project in more detail, set up a discovery call using the form opposite.

Do you want to accelerate your drug program?

Download our brochure to learn more about how our capabilities and delivery approach can help you.

Upperton Corporate Brochure