Manufacturing Clinical Supplies: The Role of Placebos and the Challenges they Present
Manufacturing a suitable placebo dosage form presents many unique challenges over and above those required for the active product.
Insight
Key Considerations when Choosing a Device for Dry Powder Nasal Delivery
Nasal Delivery The Nasal Cavity Nasal Devices Patient Profile Target Dose FAQs Nasal delivery overview Drug administration via the nasal route can be used as an efficient method of administration for both local and systemic acting drugs. The nasal route offers a range of advantages including its relative ease of use as compared to injectable … Read more
Considerations when Developing Dry Powder Formulations for Nasal Locally Delivered Drugs
By 2020, 58% of all therapeutics in development are injectable, 29% oral and 4% inhaled including nasal delivery, and while nasal delivery may not be one of the most explored routes, it has the potential to offer an alternative delivery method for therapeutics with some specific advantages. Nasal delivery of drugs has traditionally been via … Read more
A Tablet Development Journey at Upperton
With the continued expansion of our tablet formulation development services, Upperton currently have a number of tablet dosage form development projects completed or in progress. Theses tablet / solid dosage form projects have encompassed a wide range of development activities from Active Pharmaceutical Ingredient (API) characterisation and feasibility studies through the application of enabling technologies, … Read more
Stages of Tablet Development: Compression Equipment Overview
Stages of Tablet Compression Equipment Used During Formulation and Process Development Tablets are one of the most popular dosage forms used in the pharmaceutical, nutraceutical and veterinary industries due to their ease of handling and administration, stability, convenient packing options and well-established cost-effective manufacturing processes which produce consistent quality products. Developing a tablet formulation from … Read more
Formulating Spray Dried Dispersions into Tablets
What is Spray Drying? The Spray Drying Process Spray Drying Expertise Resources FAQs In this article, Upperton interviewed Dr Ian Lafferty, our Chief Technical Officer on the topic of developing spray dried dispersions (SDDs) into tablets. Ian has 25 years of technical and operational experience in early-phase pharmaceutical development encompassing the formulation design, development, process … Read more
Applications and Techniques of Pharmaceutical Granulation
What is Granulation? Wet Granulation Wet Granulation Options Dry Granulation Dry Granulation Options Loading the Elevenlabs Text to Speech AudioNative Player… What is Granulation? Granulation has been widely used in the pharmaceutical industry since the 1950s. Whilst the science remains largely identical to that developed over 70 years ago, granulation techniques and equipment have improved … Read more
Tablet Formulation: A General Overview
Tablet Formulation Strategies Solid Dosage Forms Tablet Manufacture Process Tablet Press FAQs Loading the Elevenlabs Text to Speech AudioNative Player… Tablets continue to be one of the most popular pharmaceutical dosage forms, as with the right tablet formulation you can achieve: ease of handling and administration for patients, stability convenient packing options, and well-established cost-effective … Read more
Tablets: A General Overview
What are Oral Solid Tablets? Examples of Tablets Considerations for Tablet Design FAQs Loading the Elevenlabs Text to Speech AudioNative Player… Tablet dosage forms are one of the most popular dosage forms used in the pharmaceutical industry due to their ease of handling and administration for patients, stability, convenient packing options and well-established cost-effective manufacturing … Read more
Oral Solid Dosage Forms Containing Amorphous Spray Dried Dispersions: Choices for First in Human Studies
The number of amorphous solid dispersions entering first in human (FIH) studies continues to increase, due to the growing number of novel APIs with a poor solubility profile, and associated bioavailability challenges. Spray drying is a useful technology for creating a form of amorphous solid dispersions called spray dried dispersions (SDDs). Spray drying a poorly … Read more
