Insight

Pulmonary delivery is showing increased popularity as a viable dosage form for treating local airway diseases and offers additional potential for systemic drug delivery. Within this space there are a number of delivery approaches that can be undertaken. These include dry powder inhaled formulations (DPI) and pressurised metered Dose Inhalers (pMDIs). Each of these delivery … Read more

When customers initiate discussions with Upperton, one of the first questions we are asked is “which spray dryer(s) do you have and how much material can they produce?” Whilst these are very pertinent questions, the answer is not a simple one. Selection of a spray dryer that is appropriate for the project in question needs … Read more

There are many challenges that face companies taking a NCE into early stage feasibility testing and beyond. Some of these challenges are specific to the physical and chemical properties of the molecule in question (e.g. hard to handle API) whilst other challenges are related to the embryonic stage of development that these molecules are in. … Read more

There are many challenges that face companies taking an NCE into early stage feasibility testing and beyond. Some of these challenges are specific to the physical and chemical properties of the molecule in question whilst other challenges are related to the embryonic stage of development that these molecules are in (e.g. limited API). When early stage … Read more

Oral Dosage Form Development for Clinical Manufacture Producing a spray dried powder is rarely the end of developing an oral dosage form pathway. Further processing is usually required in order to create a oral dosage form that can be administered in First-in-Human (FIH) or Proof of Concept (POC) clinical studies. The selection of a dosage … Read more

Upperton Pharma Solutions are one of the very few CDMO’s that have a bespoke, fully equipped non-GMP pilot plant designed to reduce the timelines and the costs for scale up and transfer of spray drying processes into GMP manufacturing. Spray Drying Development and Scale up Formulation and early process development studies are performed in the Upperton … Read more

Analysing Biotherapeutic Formulations There is growing interest in the use of spray drying to create biotherapeutic dry powder formulations. Spray drying is becoming increasingly viewed as a more cost-effective method for enhancing the stability of thermo-sensitive molecules (such as proteins, peptides, monoclonal antibodies and vaccines). A key aspect in the successful development of dry powder formulations … Read more

Spray Drying Biotherapeutics Dry powder formulations of Biotherapeutics eliminate the need for expensive cold chain storage and facilitate supply chain management. Lyophilisation is traditionally used for the drying process, but in recent years the semi-continuous, robust and scalable qualities of spray drying have made it the drying process of choice. With expert formulation and process … Read more