September 15th 2022 : Newsletter
Aerodynamic testing of nasal powders; The Alberta Idealized Nasal Inlet (AINI)To assist researchers and developers in testing nasal drug products, the Aerosol Research Laboratory of Alberta has recently introduced the Alberta Idealized Nasal Inlet (AINI). The design was based on rigorous numerical simulations and in vitro experiments, the results of which have shown that the AINI can accurately mimic regional deposition of nasal drug products that occurs in human nasal airway geometries. Whilst the AINI concept was originally conceived, designed and built at the University of Alberta, it is now being commercialised by Copley Scientific. The AINI accurately mimics deposition behaviour in each nasal region, allowing the collection of drug samples deposited in corresponding fractions of the nose for analysis. It is routinely fitted to the Copley NGI to capture any powder that passes through the AINI, and represents lung deposition.The AINI consists of a number of aluminium parts that can be assembled/dis-assembled with four specific deposition areas which correspond to the key areas for nasal deposition, namely:
- The vestibule (nostril); where blood flow is lower and the potential for systemic delivery is low
- The turbinates; highly vascularised membranes, priority target for systemic delivery and for localised immunisation
- The olfactory region; rich in blood vessels and site for the optic nerves to reach the brain. Believed to be the primary target for nose-to-brain delivery
- The nasopharynx; the area at the top of the throat prior to the windpipe.