The start of September is always a busy time in anyone’s calendar, whether you are a parent getting your children ready for school or a small CDMO looking to ramp up your development activities after the summer slowdown. Here at Upperton things are no different, September marks the start of what is traditionally one of … Read more
Upperton celebrated their 20th anniversary on the 31st August and to mark the occasion we are releasing a two-part newsletter. Last week Upperton’s Founder and CEO Dr Richard Johnson talked about the company’s origins, what has driven the business success and how the industry has changed. In this week’s edition Richard Johnson looks forward and … Read more
Celebrating 20 years of pharmaceutical spray drying Upperton will be celebrating its 20th anniversary on the 31st August 2019. Over this time Upperton has developed from a small consultancy business to become one of the world’s leading exponents of pharmaceutical spray drying services. To mark this occasion, we are publishing a special two-part newsletter. In … Read more
Oral Dosage Form Development for Clinical Manufacture Producing a spray dried powder is rarely the end of developing an oral dosage form pathway. Further processing is usually required in order to create a oral dosage form that can be administered in First-in-Human (FIH) or Proof of Concept (POC) clinical studies. The selection of a dosage … Read more
Upperton Pharma Solutions are one of the very few CDMO’s that have a bespoke, fully equipped non-GMP pilot plant designed to reduce the timelines and the costs for scale up and transfer of spray drying processes into GMP manufacturing. Spray Drying Development and Scale up Formulation and early process development studies are performed in the Upperton … Read more
19th March 2019 – Engineered Powder for Enhanced Pulmonary Delivery Upperton is continuing to invest in its combined spray drying and micronisation technology in order to meet increased demand. This emerging processing technology has been developed to enable the production of larger quantities of engineered powder formulations suitable for pulmonary delivery. The expansion of this service has been … Read more
Analysing Biotherapeutic Formulations There is growing interest in the use of spray drying to create biotherapeutic dry powder formulations. Spray drying is becoming increasingly viewed as a more cost-effective method for enhancing the stability of thermo-sensitive molecules (such as proteins, peptides, monoclonal antibodies and vaccines). A key aspect in the successful development of dry powder formulations … Read more
Spray Drying Biotherapeutics Dry powder formulations of Biotherapeutics eliminate the need for expensive cold chain storage and facilitate supply chain management. Lyophilisation is traditionally used for the drying process, but in recent years the semi-continuous, robust and scalable qualities of spray drying have made it the drying process of choice. With expert formulation and process … Read more
Non-GMP Pilot Plant Extended Capabilities Upperton Pharma Solutions now has a fully commissioned 60 square metre non-GMP pilot plant, mirroring our GMP manufacturing facility. The pilot plant is equipped for three scales of spray drying: ProCept 4M8-Trix for batch sizes of up to 300g Upperton Intermediate Spray Dryer for batch sizes of up to 1kg GEA … Read more
22nd January 2019 – Successful completion of EU Horizon 2020 Grant MACIVIVA In 2014, Upperton Pharma Solutions was awarded a prestigious Horizon 2020 MACIVIVA grant as part of a European consortium led by Mymetics, a pioneering company at the forefront of the development of virosome-based vaccines. The MACIVIVA goal was to develop dry powder, thermostable, cold-chain … Read more
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