News 2nd October 2019 – API Challenges in Early Stage Formulation Development, Part 1 There are many challenges that face companies taking an NCE into early stage feasibility testing and beyond. Some of these challenges are specific to the physical and chemical properties of the molecule in question whilst other challenges are related to the … Read more
News 10th September 2019 – Autumn Newsletter The start of September is always a busy time in anyone’s calendar, whether you are a parent getting your children ready for school or a small CDMO looking to ramp up your development activities after the summer slowdown. Here at Upperton things are no different, September marks the … Read more
News 3rd September 2019 – Celebrating 20 years of pharmaceutical spray drying, part 2 Upperton celebrated their 20th anniversary on the 31st August and to mark the occasion we are releasing a two-part newsletter. Last week Upperton’s Founder and CEO Dr Richard Johnson talked about the company’s origins, what has driven the business success and … Read more
Celebrating 20 years of pharmaceutical spray drying Upperton will be celebrating its 20th anniversary on the 31st August 2019. Over this time Upperton has developed from a small consultancy business to become one of the world’s leading exponents of pharmaceutical spray drying services. To mark this occasion, we are publishing a special two-part newsletter. In … Read more
Producing a spray dried powder is rarely the end of developing oral dosage form pathway. Further processing is usually required in order to create a oral dosage form that can be administered in First-in-Human (FIH) or Proof of Concept (POC) clinical studies. The selection of a dosage form will involve a number of factors, for … Read more
News 15th April 2019 – Spray Drying Process Development and Scale up Upperton Pharma Solutions are one of the very few CDMO’s that have a bespoke, fully equipped non-GMP pilot plant designed to reduce the timelines and the costs for scale up and transfer of spray drying processes into GMP. Spray Drying Development and Scale … Read more
News 19th March 2019 – Engineered Powder for Enhanced Pulmonary Delivery Upperton is continuing to invest in its combined spray drying and micronisation technology in order to meet increased demand. This emerging processing technology has been developed to enable the production of larger quantities of engineered powder formulations suitable for pulmonary delivery. The expansion of this service has … Read more
News 5th March 2019 – Analytical Techniques for Biotherapeutics Analysing Biotherapeutic Formulations There is growing interest in the use of spray drying to create biotherapeutic dry powder formulations. Spray drying is becoming increasingly viewed as a more cost-effective method for enhancing the stability of thermo-sensitive molecules (such as proteins, peptides, monoclonal antibodies and vaccines). A key … Read more
News 19th February 2019 – Biotherapeutic Formulation Development Spray Drying Biotherapeutics Dry powder formulations of Biotherapeutics eliminate the need for expensive cold chain storage and facilitate supply chain management. Lyophilisation is traditionally used for the drying process, but in recent years the semi-continuous, robust and scalable qualities of spray drying have made it the drying … Read more
News 5th February 2019 – Non-GMP Pilot Plant Extended Capabilities Upperton Pharma Solutions now has a fully commissioned 60 square metre non-GMP pilot plant, mirroring our GMP manufacturing facility. The pilot plant is equipped for three scales of spray drying: ProCept 4M8-Trix for batch sizes of up to 300g Upperton Intermediate Spray Dryer for batch sizes … Read more
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