News 27th October 2020 – Manufacturing Clinical Supplies: The Role of Placebos and the Challenges of Manufacturing they Present One aspect of clinical trial manufacturing that often slips under the radar when designing, planning, and budgeting a clinical study is the role and supply of the placebo control. A placebo is defined as a substance … Read more
Drug administration via the nasal route can be used as an efficient method of administration for both local and systemic acting drugs. The nasal route offers a range of advantages including its relative ease of use as compared to injectable administration, patient acceptability and compliance. It also provides a suitable route for those compounds that … Read more
News 21st July 2020 – Considerations when Developing Dry Powder Formulations for Nasal Locally Delivered Drugs By 2020, 58% of all therapeutics in development are injectable, 29% oral and 4% inhaled including nasal delivery, and while nasal delivery may not be one of the most explored routes, it has the potential to offer an alternative … Read more
News 12th May 2020 – A Tablet Development Journey at Upperton With the continued expansion of our tablet formulation development services, Upperton currently have a number of tablet dosage form development projects completed or in progress. Theses tablet / solid dosage form projects have encompassed a wide range of development activities from Active Pharmaceutical Ingredient … Read more
Stages of Tablet Compression Equipment Used During Formulation and Process Development Tablets are one of the most popular dosage forms used in the pharmaceutical, nutraceutical and veterinary industries due to their ease of handling and administration, stability, convenient packing options and well-established cost-effective manufacturing processes which produce consistent quality products. Developing a tablet formulation from … Read more
In this article, Upperton interviewed Dr Ian Lafferty, our Chief Technical Officer on the topic of developing spray dried dispersions (SDDs) into tablets. Ian has 25 years of technical and operational experience in early-phase pharmaceutical development encompassing the formulation design, development, process optimisation and manufacture of a wide range of dosage forms including oral solids … Read more
News Applications and Techniques of Pharmaceutical Granulation Granulation has been widely used in the pharmaceutical industry since the 1950s. Whilst the science remains largely identical to that developed over 70 years ago, granulation techniques and equipment have improved to allow for a greater number of applications in both R&D and manufacture. Granulation is a process … Read more
Tablets: A General Formulation Overview Tablets continue to be one of the most popular pharmaceutical dosage forms, as with the right tablet formulation you can achieve: ease of handling and administration for patients, stability convenient packing options, and well-established cost-effective manufacturing processes which produce consistent quality products. However, there are also disadvantages which can include: … Read more
News 28th January 2020 – Tablets: A General Overview Tablets are one of the most popular dosage forms used in the pharmaceutical industry due to their: ease of handling and administration for patients, stability, convenient packing options and well-established cost-effective manufacturing processes which produce consistent quality products. However, there are also disadvantages to presenting a … Read more
Oral Solid Dosage Forms Containing Amorphous Spray Dried Dispersions: Choices for First in Human Studies The number of amorphous solid dispersions entering first in human (FIH) studies continues to increase, due to the growing number of novel APIs with a poor solubility profile, and associated bioavailability challenges. Spray drying is a useful technology for creating … Read more
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