Dry Powder Formulation: The Next Generation
Outlining the Trends and Challenges in the Inhaled Drug Delivery Market, with a Special Focus on Dry Powder Formulation.
Insight
Nasal Inhalation Delivery – An Introduction Guide
An introduction to nasal delivery The delivery of APIs via nasal inhalation is of growing interest to companies looking to exploit the benefits of this delivery route. Delivery targets are typically broken down into three categories Local delivery to the nasal membranes (e.g. for vaccines, antivirals, prophylactics) Systemic delivery by absorption into the bloodstream (e.g. … Read more
Nasally Delivered Dry Powder Dosage Forms: Particle Size Analysis
Introduction to Nasal Delivery The delivery of APIs via nasal inhalation is of growing interest to companies looking to exploit the benefits of this delivery route.Delivery targets are typically broken down into three categories Local delivery to the nasal membranes (e.g. for vaccines, antivirals, prophylactics) Systemic delivery by absorption into the bloodstream (e.g. for fast … Read more
In Vitro Testing of Dry Powder Nasal Delivery Devices
Successful nasal drug delivery of dry powder formulations requires a delivered dose that can penetrate beyond the nasal entrance region and deposit in the peripheral nasal cavity, whilst avoiding deeper penetration to the airways of the lungs. This delivery, or deposition pattern, is determined by the aerodynamic particle size of the powder exiting the device, … Read more
Characterising the Physical Properties of Spray Dried Powders
The Benefits of Powder Characterisation When developing products containing spray dried powders it is vital that the physical properties of the powders produced are determined. The physical properties of spray dried powders provides important information that can assist during the pre-formulation screening and early process development phases since these properties will have a direct impact … Read more
Growing Interest in Nasal Drug Delivery
Nasal drug delivery route for small molecules and biologics. Recent trends have seen growing interest in exploiting nasal drug delivery as a means of delivering a wide range of drugs including small molecules and larger biologics for a wide range of indications. The nasal cavity is already a well-established delivery route capable of achieving rapid … Read more
Nasal Delivery of Therapeutics and Vaccines
Nasal delivery overview The anatomy and physiology of the nasal cavity creates a number of unique opportunities for the successful delivery of drugs and vaccines. This can be locally, systemically or directly to the central nervous system. This utility has resulted in growing interest from scientists looking to administer both therapeutic agents and vaccines via … Read more
Manufacturing Clinical Supplies: The Early Phase Clinical Manufacture Timeline
An Overview of Early Phase Clinical Manufacture Clinical trials are a critical step in pharmaceutical development, ensuring the safety and efficacy of new treatments before they reach patients. They involve a series of rigorously designed phases with specific objectives and regulatory requirements. Small pharma companies often benefit from partnering with Contract Development and Manufacturing Organizations … Read more
Manufacturing Clinical Supplies: Planning a First-in-Human Study
Clinical trials are one of the most important components of any drug development project; requiring careful planning and extensive funding. Clinical trials are conducted to improve the efficacy and quality of a drug, to determine the dose and dose escalation, and investigate toxicity. With approximately only 9% of new chemical entities garnering a commercial status, … Read more
Manufacturing Clinical Supplies: The Role of Placebos and the Challenges of Manufacturing they Present
One aspect of clinical trial manufacturing that often slips under the radar when designing, planning, and budgeting a clinical study is placebo manufacture. A placebo is defined as a substance given to someone who is told that it is a particular medicine: either to make that person feel as if they are getting better or … Read more
