PR Archives - Page 6 of 9 - Upperton Pharma Solutions

Upperton Pharma Solutions launches nasal delivery development platform

October 16, 2024April 5, 2022 by admin_upperton

5th April 2022 – Press Release Nottingham-based contract development and manufacturing organisation (CDMO), Upperton Pharma Solutions, has launched a unique nasal delivery development platform, UpperNose™, to make it easier and faster for small and mid-sized innovators to access the knowledge and capabilities necessary for the successful development of nasal dosage formulations. Drug developers seeking to … Read more

Growing Interest in Nasal Drug Delivery

November 6, 2024February 24, 2022 by admin_upperton

Nasal drug delivery route for small molecules and biologics. Recent trends have seen growing interest in exploiting nasal drug delivery as a means of delivering a wide range of drugs including small molecules and larger biologics for a wide range of indications. The nasal cavity is already a well-established delivery route capable of achieving rapid … Read more

20th May 2021 – Upperton Nasal Delivery Article Published in ONdrugDelivery

October 16, 2024May 20, 2021 by admin_upperton

20th May 2021 – Upperton Nasal Delivery Article Published in ONdrugDelivery Formulation Options In Nasal Drug Delivery Upperton had an article published in Edition 119 ONdrugDeliver in May 2021 In the article Richard Johnson, CEO and founder of Upperton, discusses the advantages of nasal delivery and why there is growing interest in this route of … Read more

Formulation Options in Nasal Drug Delivery

December 5, 2024March 24, 2021 by admin_upperton

Nasal delivery options The anatomy and physiology of the nasal cavity creates a number of unique opportunities for the successful delivery of drugs and vaccines. This can be locally, systemically or directly to the central nervous system. This utility has resulted in growing interest from scientists looking to administer both therapeutic agents and vaccines via the … Read more

Nasal Delivery of Therapeutics and Vaccines

November 22, 2024March 11, 2021 by admin_upperton

Nasal delivery overview The anatomy and physiology of the nasal cavity creates a number of unique opportunities for the successful delivery of drugs and vaccines. This can be locally, systemically or directly to the central nervous system. This utility has resulted in growing interest from scientists looking to administer both therapeutic agents and vaccines via … Read more

Manufacturing Clinical Supplies: The Early Phase Clinical Manufacture Timeline

January 21, 2025December 1, 2020 by admin_upperton

An Overview of Early Phase Clinical Manufacture Clinical trials are a critical step in pharmaceutical development, ensuring the safety and efficacy of new treatments before they reach patients. They involve a series of rigorously designed phases with specific objectives and regulatory requirements. Small pharma companies often benefit from partnering with Contract Development and Manufacturing Organizations … Read more

Manufacturing Clinical Supplies: Planning a First-in-Human Study

November 12, 2024November 9, 2020 by admin_upperton

Clinical trials are one of the most important components of any drug development project; requiring careful planning and extensive funding. Clinical trials are conducted to improve the efficacy and quality of a drug, to determine the dose and dose escalation, and investigate toxicity. With approximately only 9% of new chemical entities garnering a commercial status, … Read more

Manufacturing Clinical Supplies: The Role of Placebos and the Challenges of Manufacturing they Present

November 12, 2024October 23, 2020 by admin_upperton

One aspect of clinical trial manufacturing that often slips under the radar when designing, planning, and budgeting a clinical study is placebo manufacture. A placebo is defined as a substance given to someone who is told that it is a particular medicine: either to make that person feel as if they are getting better or … Read more

Key Considerations when Choosing a Device for Dry Powder Nasal Delivery

November 22, 2024September 23, 2020 by admin_upperton

Nasal delivery overview Drug administration via the nasal route can be used as an efficient method of administration for both local and systemic acting drugs. The nasal route offers a range of advantages including its relative ease of use as compared to injectable administration, patient acceptability and compliance. It also provides a suitable route for … Read more

Considerations when Developing Dry Powder Formulations for Nasal Locally Delivered Drugs

November 6, 2024July 20, 2020 by admin_upperton

By 2020, 58% of all therapeutics in development are injectable, 29% oral and 4% inhaled including nasal delivery, and while nasal delivery may not be one of the most explored routes, it has the potential to offer an alternative delivery method for therapeutics with some specific advantages. Nasal delivery of drugs has traditionally been via … Read more