Development of Pulmonary Dosage Forms for the Successful Delivery of Complex Molecules

This whitepaper explores the development of dry powder inhaler (DPI) and soft mist inhaler (SMI) dosage forms for pulmonary drug delivery. It highlights the formulation strategies, performance testing, and stability considerations essential for creating effective inhaled therapies.

Whitepaper Contents

• An overview of pulmonary drug delivery and the evolution of inhaler technologies
• Insights into the development of DPI and SMI formulations for deep lung delivery
• Discussion of the formulation and device-specific challenges in inhaled dosage forms
• Identification of critical techniques for measuring aerodynamic particle and droplet size
• Guidance on determining fine particle fraction and its impact on lung deposition
• Strategies for evaluating storage stability of DPI and SMI formulations
• Practical considerations for ensuring robust performance and long-term stability