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Formulation Development.

Formulation development expertise to take your project from early feasibility and into the clinic.

Formulation Development

Experts in oral, nasal, pulmonary and parenteral dosage forms

We have extensive experience in drug formulation development, taking projects from early proof of concept and feasibility, through scale up and onto clinical manufacture for oral, nasal, pulmonary and parenteral dosage forms.

We work closely with clients from the start, defining project aims and understanding the target product profile. Early development includes pre-formulation activities and excipient selection to create the ideal dosage form. Throughout, we focus on formulation suitability, scale-up potential, and commercialisation. Stability studies and extensive analytical techniques ensure product quality.

Once a formulation is ready, we scale the process in our pilot plant, equipped to mirror our GMP facility, ensuring confidence before clinical manufacture. Our team harnesses advanced formulation technologies and analytical expertise to develop innovative dosage forms across oral, nasal, pulmonary and sterile drug products.

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Oral Dosage Forms

Blending
Dry granulation
Milling
Coating
Tablets (IR, MR, SR, Minitabs)
Capsules (API, powder blend, lipid)
Small molecules, biologics, and NCEs
Batch sizes from grams to 250 kg
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Nasal & Pulmonary
Dosage Forms

Nasal Powder and liquid dosage forms
Pulmonary Powder dosage forms
Spray drying intermediates
Micronisation
Lipid-based formulations
Capsule filling
Device filling
Blister packaging
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Sterile Early Formulation Development

Pre-formulation studies
Formulation screening and optimisation
Small-scale sterile formulation development
Biologics and small molecules
Early-stage formulation feasibility
Stability assessment
Analytical development support
Early clinical development support

FORMULATION DEVELOPMENT WITH PHARMACEUTICAL SPRAY DRYING

Formulation Development For Bioavailability and Solubility Enhancement

We’re specialists in the use of pharmaceutical spray drying to improve the solubility and bioavailability of your formulation, helping to enhance the dissolution rate and stability.

Spray Drying Expertise

Upperton has over 25 years of expertise in spray drying, using specialist spray drying technology that can scale from R&D through to commercial.

Bioavailability Enhancement

Spray drying is an excellent technology that can support with bioavailability enhancement. Our spray drying technology can be used on a range of molecules.

Micronisation

Micronisation reduces the average diameter of solid material particles. By drastically increasing the surface-area-to-volume ratio, this technique significantly improves solubility and bioavailability.

YOUR STRATEGIC CDMO PARTNER

Partner with Upperton

We provide fully integrated CDMO services across every stage of the drug product lifecycle.

Award-winning for our service delivery

Formulation Development FAQs

Yes, we offer end-to-end formulation development across a range of dosage forms, including oral solids and liquids, nasal liquids and powders, pulmonary liquids and powders, in addition to sterile dosage forms

Upperton specialises in working with particularly challenging APIs, including those with low solubility, poor permeability, or chemical instability.

We prioritise stability and bioavailability from the earliest stages of formulation development. We conduct comprehensive pre-formulation studies to understand the physicochemical properties of the API. Stability is assessed through ICH-compliant stability studies under various conditions to ensure the formulation remains effective and safe throughout its shelf life.

Speak to us about our formulation development services

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