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Spray Drying of Ultra High Concentration (UHC) Biologics

Spray drying can enable ultra high concentration biologic formulations, supporting subcutaneous delivery, improved patient convenience and next-generation injectable therapies.

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Spray Dried Biologics

Accelerating the Future of Biologic Drug Delivery

As biologic therapies continue to advance, there is increasing demand for formulations that improve patient convenience while maintaining therapeutic efficacy. Ultra high concentration biologics are helping to meet this challenge by enabling large doses to be delivered in smaller volumes, opening new possibilities for subcutaneous administration and patient-centric treatment pathways.

At Upperton, we support the development and manufacture of ultra high concentration biologic formulations designed to overcome the technical challenges associated with high drug loading, viscosity management, stability, and manufacturability. Our integrated development capabilities help innovators advance promising biologics from early formulation development through to clinical manufacture.

Unlocking Subcutaneous Administration

Unlocking Subcutaneous Administration for Complex Biologics

Historically, many biologic therapies have required intravenous infusion because therapeutic doses could not be delivered in a practical injection volume. Ultra high concentration formulations overcome this limitation, enabling high-dose biologics to be administered subcutaneously while maintaining the required dose strength. This creates new opportunities for more convenient, patient-focused treatment pathways.

Transforming the Treatment Experience

Moving Beyond Lengthy Infusions

Traditional IV therapies can require significant patient time, specialised administration, and dedicated healthcare infrastructure. Ultra high concentration biologics can reduce treatment times from hours to minutes by enabling subcutaneous delivery, helping improve patient convenience, reduce pressure on healthcare resources, and support more flexible models of care.

Ultra high concentration Biologics

Why Ultra High Concentration Biologics?

Many biologic therapies have traditionally relied on intravenous (IV) administration due to the large dose volumes required. By increasing drug concentration while maintaining product quality and stability, developers can unlock alternative routes of administration that may offer significant advantages for both patients and healthcare providers.

Improved Patient Experience

Ultra high concentration formulations can enable subcutaneous administration, reducing or eliminating the need for lengthy IV infusions. This can minimise treatment disruption, reduce time spent in healthcare settings, and support more convenient dosing options for patients.

Reduced Reliance on Infusion Centres

Moving from IV administration to smaller-volume injections can help reduce demand on infusion infrastructure and clinical resources. This streamlined approach has the potential to improve treatment accessibility while creating efficiencies across healthcare systems.

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Watch our Fireside Chat exploring spray-dried biologics for injectable dosage forms.

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YOUR STRATEGIC CDMO PARTNER

Partner with Upperton

We provide fully integrated CDMO services across every stage of the drug product lifecycle.

One Site

Award-winning facility built for scale and continuity providing integrated, end-to-end capabilities delivered under one roof.

One Team

The same team from your early-stage development through to preparation for commercial readiness.

Dosage Form Expertise

Proven track record in solving formulation and delivery challenges across multiple dosage forms.

Executive Leadership on Every Project

Direct access to experienced senior leadership for strategic oversight and decision-making.

Award-winning for our service delivery

Contract Services Award - Upperton Pharma

Quality Assurance Award - Upperton Pharma

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We provide fully integrated services across every stage of drug product development.