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Trent Gateway Facility.

A purpose-built development and manufacturing facility designed to take drug products from feasibility through clinical supply and commercial readiness.

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One team. One site.

State-of-the-art drug product development and manufacturing facility in Nottingham, UK.

Our state-of-the-art Nottingham facility houses 10 GMP manufacturing suites, quality control laboratories and dedicated analytical and formulation development laboratories with pilot plant facilities.

Trent Gateway has been specifically designed to cater to a wide range of development and manufacturing projects, offering processing of non-sterile dosage forms including solids, liquids, semi-solids, nasal and inhaled products, alongside sterile liquid and dry powder drug products.

Whether you’re in the early stages of formulation development, in need of clinical trial supplies from Phase 1 to Phase 3 or seeking niche-scale commercial manufacturing, Trent Gateway is fully equipped to fulfill your requirements with precision and excellence.

About Us

GMP PROCESSING SUITES

Integrated GMP manufacturing suites supporting development and clinical manufacture.

HIGH POTENCY HANDLING

oeb5

Containment capabilities supporting the safe handling of highly potent compounds up to OEB 5.

sterile manufacturing

Annex 1

MHRA Approved sterile manufacturing facility, designed against the revised Annex -1 guidelines.

FACILITY SIZE

R&D, GMP, QC and more all on one 70,000 sq ft facility in Nottingham, UK

TRENT GATEWAY - DEVELOPMENT AND MANUFACTURING FACILITY

Designed for continuity, scale and commercial readiness.

Many CDMO programmes rely on multiple sites, multiple teams and multiple technology transfers, introducing delays and increasing risk as projects progress.

Trent Gateway was designed differently.

By bringing formulation development, analytical testing, quality control, GMP manufacturing and sterile processing together within a single integrated facility, Upperton helps preserve programme knowledge, reduce handovers and create a smoother pathway from feasibility through to clinical manufacture and commercial readiness.

For sponsors, this means greater continuity, improved communication and faster progression through development.

facility size

sq. ft sterile manufacturing facility

batch sizes

Initial batch sizes, up to 2,000 units

MHRA APPROVED

Annex 1

MHRA Approved sterile manufacturing facility, designed against the revised Annex -1 guidelines.

VIAL SIZES

2R - 20R

Flexible sterile filling capability supporting vial formats from 2R to 20R.

ANNEX 1 STERILE MANUFACTURING FACILITY

Aseptic processing of small volume liquids

Designed around modern Annex 1 guidance, our sterile manufacturing capability supports small-volume injectable products through formulation, aseptic processing and fill-finish activities within a highly controlled environment.

IMAGE GALLERY

Equipment

Research & Development

Material Sciences
+ Sympactec Laser Particle Analysis
+ Rikagu Miniflex 600-D XRPD
+ TA Dynamic Vapour Sorption Analyser (DVS)
+ TA Thermogravimetric Analyzer (TGA)
+ TA Thermal Analysis Q20 DSC+ Scanning Electron Microscope (outsourced)

Spray Drying
+ ProCepT 4M8-TriX Spray Dryer (aqueous)
+ GEA Niro SD Micro Spray Dryer (aqueous or solvent)
+ Buchi B-290 Mini Spray Dryer (aqueous or solvent)
+ GEA Niro Mobile Minor® (aqueous)

Analytical / Performance Testing
+ HPLC Agilent Series
+ Thermo Trace Gas Chromatography
+ Brookfield DV-III
+ Rheometer
+ Malvern Spraytec Laser Diffraction
+ Copley NGI (Next Generation Impactor)
+ Alberta Idealized Nasal Inlet (AINI)
+ Copley Tablet Disintegration/Hardness Tester
+ Sotax AT7 Dissolution Tester
+ Sotax Dissolution Testing USP I / USP II

Manufacturing
+ Edwards Super Modulyo Freeze Dryer
+ Quantos Precision Powder Filler
+ Atritor M3 Jet Mill
+ Freund-Vector TFC Roller Compactor & Mill
+ Natoli Single Station Tablet Press
+ Caleva Tablet and Pellet Mini Coater Dryer

GMP Manufacturing

Roller Compaction
+ Freund Vector TFC Roller Compactor & Mill
+ Gerteis® Mini-Pactor 250/25/3 Roller Compactor

Blending
+ Turbular® T10 Blender
+ Pharmatech NB100 IBC Bin Blender
+ GEA Post Hoist IBC PLB700 Blender system

High Shear / Wet Granulation
+ Diosna Laboratory Pharma Mixer

Milling
+ Ytron-Quadro - Scalable Lab system

Packaging
+ Sepha EZ Blister - blister packaging machine

Spray Drying
+ ProCepT 4M8-TriX Spray Dryer
+ GEA Niro SD Micro Spray Dryer
+ GEA Niro PSD-1 Spray Dryer
+ GEA Niro Mobile Minor®

Capsule Filling
+ Bonapace INCAP3000 Automatic Capsule Filler
+ 3P Innovation Fill2Weight Powder Filler
+ IMA Zanasi 40 Automatic Capsule Filler

High Precision Filling
+ Quantos Automated Powder Dosing
+ 3P Innovation Fill2Weight Powder Filler

Tableting
+ KG-Pharma - Futorque® X-1 Rotary Tablet Press

Tablet Coating
+ O’Hara Labcoat™ M5 Tablet Coating System
+ O’Hara Labcoat™ M50 Tablet Coating System

Sterile Manufacturing / Aseptic Processing

Sterile Processing
+ Envair CIVAS ABD positive-pressure isolators
+ Flexicon PF6 Peristaltic Aseptic Filling Machine
+ 3P Innovation Vial Rotary Crimper

Sterilization Systems
+ LAST Dry Heat Steriliser Depyrogenation Oven
+ LTE 2UCF15MP Autoclave

Performance Testing
+ Merck Integritest 5 Filter Integrity Tester
+ PUPSIT Filter Integrity Testing
+ ENDOTOXIN Testing+ Visual inspection equipment

Analytical Development & QC

Performance Testing
+ Agilent and Thermo Fisher HPLC Analytical Systems with UV-vis, DAD (Diode Array Detection) and Chromeleon™
+ Vanquish™ UHPLC Systems with Chromeleon™
+ Agilent GC with Headspace with Chromeleon™
+ Karl Fischer Moisture Content Tester
+ Tablet Tester (Hardness/Breaking Force)
+ Distek Dissolution Baths
+ Moisture Balance Analyzer for LOD Testing
+ Beckman Coulter™ Subvisible Particle Analyzer
+ Proveris Automated Actuator
+ Copley NGI (Next Generation Impactor) with DUSA collection tubes
+ Enzyme-linked immunosorbent assay (ELISA)
+ Gonotec® Osometer
+ Brookfield DV-III + Rheometerctor

Book a guided virtual tour.

Join one of our subject matter experts for a guided virtual tour of the facility. Discover our development laboratories, analytical capabilities, GMP manufacturing suites and sterile processing environments, and see how programmes progress from feasibility through clinical manufacture on a single integrated site.