This study explores how varying levels of L-Leucine influence the structure and surface composition of spray-dried particles used in inhaled drug formulations. Using advanced imaging and surface analysis techniques, the research demonstrates how L-Leucine can be used to engineer particle morphology, improve dispersibility, and optimise performance for pulmonary drug delivery.
Key Takeaways
- L-Leucine concentration significantly impacts particle structure, surface composition, and morphology.
- Higher L-Leucine levels increase surface enrichment and internal porosity within spray-dried particles.
- L-Leucine helps create particles with characteristics that can enhance inhalation performance.
- Formulation components such as Polysorbate 20 can influence how L-Leucine distributes across the particle surface.
- The findings provide valuable insight for optimising spray-dried inhalation formulations and improving lung delivery.
Download the poster to learn how excipient selection and particle engineering can be used to optimise spray-dried formulations for inhaled drug delivery.