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News

4th April 2018 - Upperton Pharma Solutions Opens New Pilot Plant for Spray Drying and Dosage Form Development

After less than two weeks in our new home we are delighted to announce that our non-GMP pilot plant has come on stream and is now available for customer use.

Our newly refurbished Pilot Plant will enable us to develop processes and produce batches of spray dried powder utilising equipment identical to that housed in our new clinical trials manufacturing plant.

The Upperton Pilot Plant now houses a range of spray dryers that can process solutions at a range of scales, namely:
  • Buchi B-290 (Typical batch sizes of 100mg to 50g spray dried powder)
     
  • ProCepT  4M8 (Typical batch sizes of 100mg to 200g spray dried powder)
     
  • Upperton Pharma Dryer (typical batch sizes of 10g to 200g spray dried powder)
     
  • Niro PSD-1 (typical batch sizes of 20g to 2kg spray dried powder)

In addition to our range of extensive spray dryers we have also incorporated a range of additional processes to assist in dosage form development. All of these are available at pilot plant scale including;
  • Blending and secondary drying of spray dried powders
     
  • Dry and wet granulation and granule coating
     
  • Powder densification, slugging and sieving
     
  • Capsule filling and enteric coating
     
  • Tabletting

Drop us a line today to talk about our streamline service for research here
 

14th March 2018 - Upperton Pharma Solutions to offer cGMP spray drying and clinical trials manufacturing service

Upperton Pharma Solutions is pleased to announce that the company has relocated to larger, self-contained facilities at Highfields Science Park, adjacent to the University of Nottingham. The move to new premises underlines the company’s rapid expansion and will enable it to develop its own cGMP manufacturing capabilities for early phase clinical trials.

The 15,000 square foot facility will house all of the company’s R&D team, as well as its fast-growing Quality Assurance and Manufacturing departments. Within the building is a clean room suite suitable for cGMP manufacture, and a pilot plant for non-GMP intermediate scale manufacturing. Upperton plans to have an MHRA licence for clinical trials manufacturing by Q3 of 2018.




The relocation and expansion will allow the company to offer a full integrated pharmaceutical development service, from early feasibility studies through to cGMP manufacture to support clinical trials. The extended range of capabilities includes:
  • cGMP manufacturing for clinical trials, release testing and QP release
  • Range of additional powder handling and filling capabilities
  • Enhanced dosage form development service
  • Expanded analytical service

In the coming weeks we will be sharing more news about our move and the new services we will be offering our customers.

Upperton R&D Director to speak at Spray Drying Conference on 20th-22nd March 2018

Upperton will be presenting at Spray Drying and Atomisation of Formulations the University of Leeds 20-22nd March 2018 at Faculty of Engineering, Leeds University. The course is the UK’s leading conference dedicated to the science and engineering of spray drying The talk entitled “Spray Drying of Pharmaceuticals” will be given by Dr Andrew Naylor on the 21st March 2018

ProCepT Spray dryer

A new 4M8-Trix ProCepT spray dryer has been delivered and is now being commissioned at Upperton. It brings the number of spray dryers that we have in our laboratory and pilot plant to eleven.

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Upperton installs Quantos Micro-dosing system for capsule and device filling

Nottingham, UK – 18th November, 2016 —Upperton is pleased to announce that it has acquired a Quantos MicroDosing unit that can be used to precisely fill a range of dosage forms including capsules, and devices for inhaled and nasal drug delivery. The new Quantos system is capable of dosing to an accuracy of ± 0.5mg, independent of substance characteristics, operator or environmental conditions. The system learns the characteristics of a product, with an RFID chip present in the dosing head storing all the key information on the substance used, including batch number and powder characteristics. Actual fill weights of each individual capsule or device are captured electronically and can be printed if required.

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Upperton establishes spray drying partnership with Quotient Clinical

Nottingham, UK – 28th May, 2016 — Upperton has entered into a partnership with Quotient Clinical, the Translational Pharmaceutics® Company, to deliver a complete spray drying service for pharmaceutical and biotechnology companies seeking to develop spray dried formulations for clinical use. The partnership will see Upperton working with Quotient Clinical to supply GMP manufacturing services at Quotient within the MediCity life science innovation hub in Nottingham, UK.

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About Us

With over 20 years of experience we have successfully spray dried, formulated and characterised a vast range of pharmaceutical and biotechnology products for companies across the globe.

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- Address

Upperton Pharma Solutions,
Albert Einstein Centre,
Nottingham Science & Technology Park,
Nottingham
NG7 2TN

- Contact
+44 (0)115 855 7050
enquiry@upperton.com